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Talks from the Sackler Colloquium on Telomerase and Retrotransposons

Here is the link to the Sackler Colloquium on Telomerase and Retrotransposons.

Not all talks are available, but most are.

Telomerase and Retrotransposons:
Reverse Transcriptases That Shaped Genomes

Organized by M. Joan Curcio, Neal Lue, and Marlene Belfort
September 29-30, 2010
Beckman Center, Irvine, CA

Meeting Overview

Misregulation of telomerase and retrotransposon reverse transcriptases has been implicated in genome restructuring events that promote cancer and aging.  A central question in genome biology is how the activity of reverse transcriptases has been modified and harnessed throughout archaeal, bacterial and eukaryotic evolution to generate diversity and at the same time, participate in the maintenance of genome integrity. It has been appreciated for quite some time that telomerase and retrotransposon reverse transcriptases exhibit a number of mechanistic similarities and are likely to share a common origin. More recent biochemical, functional and phylogenetic analyses only serve to reinforce a deep-seated connection between these two families of polymerases.

In recognition of the 40-year anniversary of the discovery of reverse transcriptase, this colloquium will bring researchers in the two fields together to identify common and distinguishing attri butes of telomerase and retrotransposon reverse transcriptases. Recent advances in understanding the chemistry, biology and evolution of these two classes of reverse transcriptases, and the implications of these studies for improving human health will be examined.

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