All of us are familiar with Endnote or Reference Manager, including all the troubles it causes when trying to use it. Now there is a new option which has been in beta-mode for a while: mendeley and it’s free. It not only does the same things as Endnote and alikes, it also looks for duplicate articles you have, open pdf’s inside the program, and you can share your articles with fellow researchers, as in social networking. Oh, did I already mention it is free?
What is Mendeley? from Mendeley on Vimeo.
Also note, that one of our professors, Jonathan Eissen, likes this program. He is an advocate for Open Access in science.