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Autophagy, tumors and recycling proteins
From the BBC by James Gallagher:
Protein recycling in the body could be a critical part of tumour formation, researchers believe.
A report in Science Translational Medicine showed that protein recycling was accelerated in more than 30 types of cancerous cell.
When scientists interrupted the process in mice with cancer, the tumours began to shrink.
The results were described as “exciting” and as a new target for drug development.
The recycling process studied was “chaperone-mediated autophagy” (CAM). It is a normal part of a cell’s routine, removing damaged goods and recycling the raw materials.
Prof Ana Cuervo, one of the researchers at Albert Einstein College of Medicine of Yeshiva University, believes cancerous cells are using this process in order to fuel their abnormally rapidly growth.
“Cancer cells seem to have learned how to optimise this system to obtain the energy they need,” she said.
Read the complete news article here. Read the original manuscript via Science.