Home > Uncategorized > Charlie Arntzen’s Group Produces Stable Synthetic Ebola Vaccine

Charlie Arntzen’s Group Produces Stable Synthetic Ebola Vaccine

Around 1,200 people have died of Ebola virus infection since 1976

 

In a PNAS paper by Phoolcharoena, Dye et. al titled “A nonreplicating subunit vaccine protects mice against lethal Ebola virus challenge” they report that using Ebola glycoproteins coupled antibodies to create Ebola immune complexes (EICs), and coupling these EICs with the Toll-like receptor antagonist polyinosinic:polycytidylic acid (PIC) resulted in an 80% survival rate of mice infected with a lethal challenge of Ebola virus. This is significant because the biggest challenge to making an effective Ebola vaccine has been cost and long term stability, this research shows immense promise that a synthetic vaccine will be cheaper, and far more stable than deactivated Ebola viruses.

A less scientific summary from the BBC

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